Principal Scientist of AI-Driven Protein design Job at Innovent Biologics, Palo Alto, CA

bmdUeFBSZXYrYkY4VGgzaU03VTVEMDBtRHc9PQ==
  • Innovent Biologics
  • Palo Alto, CA

Job Description

Job Responsibilities

  1. AI/ML-Driven Design: Lead the team in developing or utilizing state-of-the-art machine learning tools for de novo protein or antibody design; spearhead the development of novel antibody discovery methodologies.
  2. Computational Tool Development: Develop or leverage open-source models, train them using internal datasets, fine-tune models as needed, and perform multi-parameter optimization of antibodies (e.g., affinity, selectivity, half-life, drug-like properties).
  3. Cross-Functional Collaboration: Work closely with antibody engineering, structural biology, and therapeutic teams to translate AI predictions into physical molecules and effectively conduct wet lab validation.
  4. Technology Exploration: Track breakthroughs in AI/ML and computational biology; lead external collaborations (e.g., with academia/AI companies) to build Innovent’s AI development ecosystem.
  5. Strategic Leadership: Develop the team’s AI/ML technology roadmap, cultivate computational biology talent, and drive innovative molecular entities into the pipeline.

Qualifications

1.Education & Experience:

  • Ph.D. in Computational Biology, Bioinformatics, Computer Science, or a related field, with a focus on AI/ML applications in life sciences; minimum 3 years of relevant experience.
  • Experience in de novo protein design and antibody engineering is preferred.
  • Prior success in leading AI/ML projects within pharmaceutical, biotech, or research institutions is highly desirable.
  • Experience managing and developing ML/AI scientist teams; excellent communication skills to convey complex technical concepts to cross-functional colleagues; proven ability to collaborate effectively in interdisciplinary teams.

2.Technical Expertise:

  • Deep knowledge of protein structure analysis, antibody biology, and therapeutic antibody design principles.
  • Proficiency in protein modeling and structural analysis software (e.g., Rosetta, PyMOL, MOE, or equivalents).
  • Extensive experience with generative AI; hands-on practice with cutting-edge ML tools (e.g., AlphaFold, RFdiffusion, ProteinMPNN, or similar models).
  • Core competency in developing and implementing ML algorithms; proficiency in Python/R/C++ and deep learning architectures (e.g., CNNs, RNNs, Transformers).
  • Expertise in advanced ML models for protein modeling, including generative models (diffusion, flow matching), language models (Transformers), multimodal learning, geometric deep learning, and graph representation learning.

3.Results-Driven:

  • Published original research on AI applications in biomedicine in top-tier journals/conferences.
  • Delivered presentations on AI/ML topics at conferences on behalf of companies or research institutions.

Job Tags

Similar Jobs

CEVA Logistics

Quality and Safety Coordinator Job at CEVA Logistics

 ...Your Role Are you a detail-oriented leader with a strong background in safety, compliance, and continuous improvement? We are seeking a Quality & Safety Coordinator to oversee and drive the quality and safety performance across field contract locations. In this role... 

Fresh Baguette

Baker Job at Fresh Baguette

Fresh Baguette is a fast-growing, artisanal bakery known for its high-quality standards and modern atmosphere. The company was founded in Bethesda, MD in 2013, to bring fresh, made-from-scratch organic breads, pastries, sweets, and croissant itemsinspired by bakeries...

Team Sunshine Construction, LLC

Inspection Sitter Job at Team Sunshine Construction, LLC

 .... Strong attention to detail Previous solar experience is a plus. Responsibilities The responsibility of an Inspection Sitter is to represent the company at Team Sunshine customers' homes prior to the solar inspection. The Technician will meet with the Municipal... 

Eastridge Workforce Solutions

Recruiter Job at Eastridge Workforce Solutions

 ...POSITION TITLE: Recruiter LOCATION: Massachusetts (Hybrid; combination of remote work and on-site visits to client locations in Devens and Westboro) COMPENSATION: $55,000 - $60,000 GENERAL JOB DESCRIPTION: Our team is looking for a Recruiter for a long-term opportunity... 

Bayside Solutions

Business Analyst Job at Bayside Solutions

 ...Business Analyst W2 Contract Salary Range: $104,000 - $124,800 per year Location: Dublin, CA - Hybrid Role Duties and Responsibilities: Documentation for reporting requirements Data validation Create testing scenarios for pre-UAT and UAT for the reporting...